Check Intently (two)pentobarbital will reduce the extent or result of suvorexant by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Observe. Robust CYP3A4 inducers may perhaps reduce suvorexant efficacy; if increased suvorexant dose essential, never exceed 20 mg/daypentobarbital will decrease the level or outcome of bexarotene by